Install of Windows Vista set-up fails

Hello Everyone
I can download Repetier-Host, but when I click "setup", nothing happens. Everything else on the computer works fine.  Windows Vista has all the updates installed.
I had Repetier-Host running fine on this computer for a week or two (except I could never see the image of the router path.  I had to reinstall OS with updates to solve a crashing problem with another software, now I'm having this problem.
Has anyone else had this problem?
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