Looking into sources I see
#if TMC2130_ON_EXT1 > 0
Printer::tmc_driver_e1 = new TMC2130Stepper(EXT1_ENABLE_PIN, EXT1_DIR_PIN, EXT1_STEP_PIN, TMC2130_EXT1_CS_PIN);
configTMC2130(Printer::tmc_driver_e1, TMC2130_STEALTHCHOP_EXT1, TMC2130_STALLGUARD_EXT1,
TMC2130_PWM_AMPL_EXT1, TMC2130_PWM_GRAD_EXT1, TMC2130_PWM_AUTOSCALE_EXT1, TMC2130_PWM_FREQ_EXT1);
#endif
so in your case not having second extruder TMC2130_ON_EXT1 0 is required. That means
E1 CS PinTMC2130_E1_CS_PIN
should be disabled.
I guess you used this as second z drive? Not sure this is fully supported. I show the thread to the TMC2130 author. Maybe he can say more.